Abstract
Reduced glutathione, most commonly called glutathione or GSH, is a relatively small molecule ubiquitous in living systems.1-3 Occurring naturally in all human cells, GSH is a water-phase orthomolecular. Its intracellular depletion ultimately results in cell death and its clinical relevance has been researched for decades.4 GSH is the smallest intracellular thiol (–SH) molecule. Its high electron-donating capacity (high negative redox potential) combined with high intracellular concentration (millimolar levels) generate great reducing power.2 This characteristic underlies its potent antioxidant action and enzyme cofactor properties, and supports a complex thiol-exchange system, which hierarchically regulates cell activity.